Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50132140
Substrate
n/a
Meas. Tech.
ChEMBL_536825 (CHEMBL988089)
Ki
156±n/a nM
Citation
 Boatman, PD; Richman, JG; Semple, G Nicotinic acid receptor agonists. J Med Chem 51:7653-62 (2008) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50132140
Synonyms:
1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid | 1,4,5,6-Tetrahydrocyclopenta[c]pyrazole-3-carboxylic Acid | 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylate | 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid | CHEMBL128604
Type:
Small organic molecule
Emp. Form.:
C7H8N2O2
Mol. Mass.:
152.1506
SMILES:
OC(=O)c1n[nH]c2CCCc12
Structure:
Search PDB for entries with ligand similarity: