Target
Leukotriene A-4 hydrolase
Ligand
BDBM50266170
Substrate
n/a
Meas. Tech.
ChEMBL_544515 (CHEMBL1013487)
IC50
280±n/a nM
Citation
 Enomoto, HMorikawa, YMiyake, YTsuji, FMizuchi, MSuhara, HFujimura, KHoriuchi, MBan, M Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 19:442-6 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_CAVPO | LTA4H
Type:
PROTEIN
Mol. Mass.:
68972.78
Organism:
Cavia porcellus
Description:
ChEMBL_544515
Residue:
611
Sequence:
MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
  
Inhibitor
Name:
BDBM50266170
Synonyms:
(R)-3-(4-ethylbenzylthio)-2-((S)-3-mercapto-2-methylpropanamido)propanoic acid | CHEMBL511184
Type:
Small organic molecule
Emp. Form.:
C16H23NO3S2
Mol. Mass.:
341.489
SMILES:
CCc1ccc(CSC[C@H](NC(=O)[C@H](C)CS)C(O)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: