Target
Leukotriene A-4 hydrolase
Ligand
BDBM50266079
Substrate
n/a
Meas. Tech.
ChEMBL_544515 (CHEMBL1013487)
IC50
470±n/a nM
Citation
 Enomoto, HMorikawa, YMiyake, YTsuji, FMizuchi, MSuhara, HFujimura, KHoriuchi, MBan, M Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 19:442-6 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_CAVPO | LTA4H
Type:
PROTEIN
Mol. Mass.:
68972.78
Organism:
Cavia porcellus
Description:
ChEMBL_544515
Residue:
611
Sequence:
MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
  
Inhibitor
Name:
BDBM50266079
Synonyms:
(R)-3-(4-(dimethylamino)benzylthio)-2-(2-mercaptoacetamido)propanoic acid | CHEMBL456035
Type:
Small organic molecule
Emp. Form.:
C14H20N2O3S2
Mol. Mass.:
328.45
SMILES:
CN(C)c1ccc(CSC[C@H](NC(=O)CS)C(O)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: