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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50266109
Substrate
n/a
Meas. Tech.
ChEMBL_544515 (CHEMBL1013487)
IC50
7400±n/a nM
Citation
 Enomoto, H; Morikawa, Y; Miyake, Y; Tsuji, F; Mizuchi, M; Suhara, H; Fujimura, K; Horiuchi, M; Ban, M Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett 19:442-6 (2008) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_CAVPO | LTA4H
Type:
PROTEIN
Mol. Mass.:
68972.78
Organism:
Cavia porcellus
Description:
ChEMBL_544515
Residue:
611
Sequence:
MPEVVDTCSLASPATVCRTKHLHLRCSVDFTRRALTGVAALTIQSQEDNLRSLILDTKDLTIEKVVINGQEVKYALGEKQSYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAFLPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPADPSRKIYKFSQKVPIPCYLIALVVGALESRKIGPRTLVWSEKEQVDKSAYEFSETESMLKIAEDLGGPYVWGQYDRLVLPPSFSYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHTWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTVKTLGETQAFTKLVVDLTDTDPDVAYSSVPYEKGFALLFHLEQLLGGPEVFLGFLKAYVEKFSYKSITTDDWKNFLFSHFKDKVDILNQVDWDAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEKDLNTFSATDLKDLSSHQVNEFLAQVLQRAPLPLGHVKRMQEVYNCNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIQTYHAHKASMHPVTAMLVGKDLKVE
  
Inhibitor
Name:
BDBM50266109
Synonyms:
(2R)-3-(4-(dimethylamino)benzylthio)-2-(3-mercaptobutanamido)propanoic acid | CHEMBL467562
Type:
Small organic molecule
Emp. Form.:
C16H24N2O3S2
Mol. Mass.:
356.503
SMILES:
CC(S)CC(=O)N[C@@H](CSCc1ccc(cc1)N(C)C)C(O)=O |r|
Structure:
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