Target
Lipoprotein lipase
Ligand
BDBM50254339
Substrate
n/a
Meas. Tech.
ChEMBL_559993 (CHEMBL1018743)
IC50
130±n/a nM
Citation
 Goodman, KBBury, MJCheung, MCichy-Knight, MADowdell, SEDunn, AKLee, DLieby, JAMoore, MLScherzer, DASha, DSuarez, DPMurphy, DJHarpel, MRManas, ESMcNulty, DEAnnan, RSMatico, RESchwartz, BKTrill, JJSweitzer, TDWang, DYKeller, PMKrawiec, JAJaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett 19:27-30 (2008) [PubMed]  Article 
Target
Name:
Lipoprotein lipase
Synonyms:
LIPL_RAT | Lpl
Type:
PROTEIN
Mol. Mass.:
53093.31
Organism:
Rattus norvegicus
Description:
ChEMBL_559993
Residue:
474
Sequence:
MESKALLLVALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDWWSSPSFVIEKIRVKAGETQKKVIFCAREKVSHLQKGKDAAVFVKCHDKSLKKSG
  
Inhibitor
Name:
BDBM50254339
Synonyms:
1-(4-methoxyphenyl)-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)urea | CHEMBL468071
Type:
Small organic molecule
Emp. Form.:
C18H23N3O5S
Mol. Mass.:
393.457
SMILES:
COc1ccc(NC(=O)Nc2cc(oc2C)S(=O)(=O)N2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: