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Target
Beta-3 adrenergic receptor
Ligand
BDBM50275224
Substrate
n/a
Meas. Tech.
ChEMBL_494295 (CHEMBL938627)
IC50
1760±n/a nM
Citation
 Shakya, N; Roy, KK; Saxena, AK Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as beta3-adrenergic receptor agonists: design, synthesis, biological evaluation and pharmacophore modeling. Bioorg Med Chem 17:830-47 (2009) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50275224
Synonyms:
1-(1-Benzyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-3-[4-(4-fluorophenyl)pipera-zin-1-yl] propan-2-ol | CHEMBL488793
Type:
Small organic molecule
Emp. Form.:
C29H34FN3O2
Mol. Mass.:
475.5976
SMILES:
OC(COc1ccc2N(Cc3ccccc3)CCCc2c1)CN1CCN(CC1)c1ccc(F)cc1
Structure:
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