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Target
Aldo-keto reductase family 1 member A1
Ligand
BDBM26269
Substrate
n/a
Meas. Tech.
ChEMBL_515733 (CHEMBL1023735)
IC50
11300±n/a nM
Citation
 Carbone, V; Zhao, HT; Chung, R; Endo, S; Hara, A; El-Kabbani, O Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem 17:1244-50 (2009) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member A1
Synonyms:
AK1A1_PIG | AKR1A1 | ALR | ALR1 | Aldehyde reductase
Type:
PROTEIN
Mol. Mass.:
36557.09
Organism:
Sus scrofa
Description:
ChEMBL_615076
Residue:
325
Sequence:
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIYGNELEIGEALTETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRKVICIPKSVTPSRILQNIQVFDFTFSPEEMKQLDALNKNLRFIVPMLTVDGKRVPRDAGHPLYPFNDPY
  
Inhibitor
Name:
BDBM26269
Synonyms:
3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichlorosalicylic acid | CHEMBL449129
Type:
Small organic molecule
Emp. Form.:
C7H4Cl2O3
Mol. Mass.:
207.011
SMILES:
OC(=O)c1cc(Cl)cc(Cl)c1O
Structure:
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