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Target
Potassium voltage-gated channel subfamily KQT member 1
Ligand
BDBM50279703
Substrate
n/a
Meas. Tech.
ChEMBL_545265 (CHEMBL1020711)
IC50
22±n/a nM
Citation
 Du, L; Li, M; Yang, Q; Tang, Y; You, Q; Xia, L Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers. Bioorg Med Chem Lett 19:1477-80 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 1
Synonyms:
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNQ1 | KCNQ1_CAVPO | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1
Type:
PROTEIN
Mol. Mass.:
74450.11
Organism:
Cavia porcellus
Description:
ChEMBL_88894
Residue:
671
Sequence:
MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGALSPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVRKKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHFMRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQLTVPQRGPDEAS
  
Inhibitor
Name:
BDBM50279703
Synonyms:
1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(4-(4-methylpiperazin-1-yl)butyl)imidazolidine-2,4-dione | CHEMBL475111
Type:
Small organic molecule
Emp. Form.:
C25H37N5O4
Mol. Mass.:
471.5924
SMILES:
CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1 |w:13.13|
Structure:
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