Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50256996
Substrate
n/a
Meas. Tech.
ChEMBL_562513 (CHEMBL1014505)
IC50
120±n/a nM
Citation
Manku, S; Allan, M; Nguyen, N; Ajamian, A; Rodrigue, J; Therrien, E; Wang, J; Guo, T; Rahil, J; Petschner, AJ; Nicolescu, A; Lefebvre, S; Li, Z; Fournel, M; Besterman, JM; Déziel, R; Wahhab, A Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors. Bioorg Med Chem Lett 19:1866-70 (2009) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
Inhibitor
Name:
BDBM50256996
Synonyms:
(S)-benzyl 1-(4-(4-methoxyphenyl)thiazol-2-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate | CHEMBL514478
Type:
Small organic molecule
Emp. Form.:
C24H29N5O6S2
Mol. Mass.:
547.647
SMILES:
COc1ccc(cc1)-c1csc(NC(=O)[C@H](CCCCNS(N)(=O)=O)NC(=O)OCc2ccccc2)n1 |r|