Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50241428
Substrate
n/a
Meas. Tech.
ChEMBL_498925 (CHEMBL975366)
Ki
7100±n/a nM
Citation
 Navarrete-Vazquez, G; Paoli, P; León-Rivera, I; Villalobos-Molina, R; Medina-Franco, JL; Ortiz-Andrade, R; Estrada-Soto, S; Camici, G; Diaz-Coutiño, D; Gallardo-Ortiz, I; Martinez-Mayorga, K; Moreno-Díaz, H Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity. Bioorg Med Chem 17:3332-41 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50241428
Synonyms:
CHEMBL401612 | N-(6-Methyl-1,3-benzothiazol-2-yl)-4-nitro benzenesulfonamide | N-(6-methylbenzo[d]thiazol-2-yl)-4-nitrobenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C14H11N3O4S2
Mol. Mass.:
349.385
SMILES:
Cc1ccc2nc(NS(=O)(=O)c3ccc(cc3)[N+]([O-])=O)sc2c1
Structure:
Search PDB for entries with ligand similarity: