Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50258659
Substrate
n/a
Meas. Tech.
ChEMBL_519771 (CHEMBL957801)
EC50
7130±n/a nM
Citation
 Bridges, TMMarlo, JENiswender, CMJones, CKJadhav, SBGentry, PRPlumley, HCWeaver, CDConn, PJLindsley, CW Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem 52:3445-8 (2009) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50258659
Synonyms:
5-fluoro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione | CHEMBL512977
Type:
Small organic molecule
Emp. Form.:
C16H9F4NO2
Mol. Mass.:
323.2418
SMILES:
Fc1ccc2N(Cc3ccc(cc3)C(F)(F)F)C(=O)C(=O)c2c1
Structure:
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