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Target
Cell division cycle 7-related protein kinase
Ligand
BDBM50279340
Substrate
n/a
Meas. Tech.
ChEMBL_546026 (CHEMBL1034201)
IC50
4±n/a nM
Citation
 Ermoli, A; Bargiotti, A; Brasca, MG; Ciavolella, A; Colombo, N; Fachin, G; Isacchi, A; Menichincheri, M; Molinari, A; Montagnoli, A; Pillan, A; Rainoldi, S; Sirtori, FR; Sola, F; Thieffine, S; Tibolla, M; Valsasina, B; Volpi, D; Santocanale, C; Vanotti, E Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships. J Med Chem 52:4380-90 (2009) [PubMed]  Article 
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Inhibitor
Name:
BDBM50279340
Synonyms:
(Z)-2-[(Furan-2-ylmethyl)-amino]-5-[1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methylidene]-thiazol-4-one | CHEMBL484146
Type:
Small organic molecule
Emp. Form.:
C16H12N4O2S
Mol. Mass.:
324.357
SMILES:
O=C1N=C(NCc2ccco2)SC1=Cc1c[nH]c2ncccc12 |w:13.15,t:2|
Structure:
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