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Target5-enolpyruvylshikimate-3-phosphate synthase
LigandBDBM50281998
Substrate/Competitorn/a
Meas. Tech.ChEBML_64958
IC50>90000000±n/a nM
Citation Miller, MJAnderson, KSBraccolino, DSCleary, DGGruys, KJHan, CYLin, KCPansegrau, PDReam, JESammons, RDSikorski, JA EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics. Bioorg Med Chem Lett3:1435-1440 (1993)    Article
More Info.:Get all data from this article,  Assay Method
 
5-enolpyruvylshikimate-3-phosphate synthase
Name:5-enolpyruvylshikimate-3-phosphate synthase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:46089.22
Organism:Escherichia coli (strain K12)
Description:ChEMBL_65087
Residue:427
Sequence:
MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL
GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR
MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA
PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE
GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE
LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE
EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL
ARISQAA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50281998
NameBDBM50281998
Synonyms:(3R,4S,5R)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid | 3alpha,4alpha,5beta-trihydroxy-1-cyclohexene-1-carboxylic acid | CHEMBL290345 | [3R-(3alpha,4alpha,5beta)]-3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid | shikimic acid
TypeSmall organic molecule
Emp. Form.C7H10O5
Mol. Mass.174.1513
SMILESO[C@@H]1CC(=C[C@@H](O)[C@H]1O)C(O)=O |r,c:3|
Structure
n/a