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Target
Aldehyde dehydrogenase, cytosolic 1
Ligand
BDBM50085551
Substrate
n/a
Meas. Tech.
ChEMBL_482174 (CHEMBL960208)
IC50
6000±n/a nM
Citation
 Shin, KH; Woo, WS; Lim, SS; Shim, CS; Chung, HS; Kennelly, EJ; Kinghorn, AD Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens J Nat Prod 60:1180-1182 (1997)    Article 
Target
Name:
Aldehyde dehydrogenase, cytosolic 1
Synonyms:
AL1A7_RAT | Aldh-pb | Aldh1 | Aldh1a4 | Aldh1a7
Type:
PROTEIN
Mol. Mass.:
54563.57
Organism:
Rattus norvegicus
Description:
ChEMBL_482174
Residue:
501
Sequence:
MSSPAQPAVPAPLANLKIQHTKIFINNEWHNSLNGKKFPVINPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGCLLNKLADLMERDRVLLATMESMNAGKIFTHAYLLDTEVSIKALKYFAGWADKIHGQTIPSDGDVFTYTRREPIGVCGQIIPWNGPLILFIWKIGAALSCGNTVIVKPAEQTPLTALYMASLIKEAGFPPGVVNVVPGYGSTAGAAISSHMDIDKVSFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYVLGNPLDSGISQGPQIDKEQHAKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDEVIKRANNTPYGLAAGVFTKDLDRAITVSSALQAGTVWVNCYLTLSVQCPFGGFKMSGNGREMGEQGVYEYTELKTVAMKISQKNS
  
Inhibitor
Name:
BDBM50085551
Synonyms:
1,8-Dihydroxy-3-hydroxymethyl-anthraquinone | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione | CHEMBL40275 | aloe emodin | aloe-emodin | cid_10207
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
Structure:
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