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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM18137
Substrate
n/a
Meas. Tech.
ChEMBL_571203 (CHEMBL1031962)
IC50
1300±n/a nM
Citation
 Heng, S; Gryncel, KR; Kantrowitz, ER A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem 17:3916-22 (2009) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM18137
Synonyms:
AMP | CHEMBL752 | US11185100, TABLE 7.3 | [(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate | adenosine 5 -monophosphate | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H14N5O7P
Mol. Mass.:
347.2212
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Structure:
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