Target
DNA (cytosine-5)-methyltransferase 3B
Ligand
BDBM50294575
Substrate
n/a
Meas. Tech.
ChEMBL_575600 (CHEMBL1036445)
IC50
>45000±n/a nM
Citation
 Isakovic, LSaavedra, OMLlewellyn, DBClaridge, SZhan, LBernstein, NVaisburg, AElowe, NPetschner, AJRahil, JBeaulieu, NGauthier, FMacLeod, ARDelorme, DBesterman, JMWahhab, A Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett 19:2742-6 (2009) [PubMed]  Article 
Target
Name:
DNA (cytosine-5)-methyltransferase 3B
Synonyms:
DNM3B_HUMAN | DNMT3B
Type:
PROTEIN
Mol. Mass.:
95771.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473708
Residue:
853
Sequence:
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
  
Inhibitor
Name:
BDBM50294575
Synonyms:
(2S,3R,4S,5S)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(((S)-pyrrolidin-3-ylthio)methyl)tetrahydrofuran-3,4-diol | CHEMBL538627
Type:
Small organic molecule
Emp. Form.:
C14H19ClN6O3S
Mol. Mass.:
386.857
SMILES:
Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CS[C@H]2CCNC2)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: