Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50296994
Substrate
n/a
Meas. Tech.
ChEMBL_580972 (CHEMBL1054937)
IC50
13±n/a nM
Citation
 Shoji, YTakahashi, KOhta, MKasai, MKunishiro, KKanda, MYogai, STakeuchi, YShirahase, H Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities. Bioorg Med Chem 17:6020-31 (2009) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50296994
Synonyms:
CHEMBL561939 | N-(5-Methanesulfonylamino-4,6-dimethyl-1-octylindolin-7-yl)-2,2-dimethylpropanamide
Type:
Small organic molecule
Emp. Form.:
C24H41N3O3S
Mol. Mass.:
451.666
SMILES:
CCCCCCCCN1CCc2c1c(NC(=O)C(C)(C)C)c(C)c(NS(C)(=O)=O)c2C
Structure:
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