Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50300577
Substrate
n/a
Meas. Tech.
ChEMBL_588964 (CHEMBL1056159)
Ki
>10000±n/a nM
Citation
 Marino, JPKallander, LSMa, COh, HJLee, DGaitanopoulos, DEKrawiec, JAParks, DJWebb, CLZiegler, KJaye, MThompson, SK The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages. Bioorg Med Chem Lett 19:5617-21 (2009) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50300577
Synonyms:
(R)-2-(3-(4-((2-chloro-3-(trifluoromethyl)benzyl)(2,2-diphenylethyl)amino)butan-2-yloxy)phenyl)acetic acid | CHEMBL573651
Type:
Small organic molecule
Emp. Form.:
C34H33ClF3NO3
Mol. Mass.:
596.079
SMILES:
C[C@H](CCN(CC(c1ccccc1)c1ccccc1)Cc1cccc(c1Cl)C(F)(F)F)Oc1cccc(CC(O)=O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: