Target
Transthyretin
Ligand
BDBM11022
Substrate
n/a
Meas. Tech.
ChEMBL_599726 (CHEMBL1048170)
IC50
>50000±n/a nM
Citation
 González, AQuirante, JNieto, JAlmeida, MRSaraiva, MJPlanas, AArsequell, GValencia, G Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorg Med Chem Lett 19:5270-3 (2009) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM11022
Synonyms:
2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | Isatin | Isatin (Compound 1)
Type:
Small organic molecule
Emp. Form.:
C8H5NO2
Mol. Mass.:
147.1308
SMILES:
O=C1Nc2ccccc2C1=O
Structure:
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