Target
Tyrosine-protein kinase Lck
Ligand
BDBM50301608
Substrate
n/a
Meas. Tech.
ChEMBL_600521 (CHEMBL1049046)
IC50
0.45±n/a nM
Citation
 Hunt, JABeresis, RTGoulet, JLHolmes, MAHong, XJKovacs, EMills, SGRuzek, RDWong, FHermes, JDPark, YWSalowe, SPSonatore, LMWu, LWoods, AZaller, DMSinclair, PJ Disubstituted pyrimidines as Lck inhibitors. Bioorg Med Chem Lett 19:5440-3 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50301608
Synonyms:
CHEMBL566507 | ethyl 2-((S)-2-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylamino)ethyl)-4-(naphthalen-1-ylcarbamoyl)piperazin-1-yl)acetate
Type:
Small organic molecule
Emp. Form.:
C32H34N8O3
Mol. Mass.:
578.6642
SMILES:
CCOC(=O)CN1CCN(C[C@H]1[C@H](C)Nc1nccc(n1)-n1cnc2ccccc12)C(=O)Nc1cccc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: