Target
Neutrophil elastase
Ligand
BDBM50303436
Substrate
n/a
Meas. Tech.
ChEMBL_595914 (CHEMBL1041780)
IC50
85113.8±n/a nM
Citation
 Mott, BTFerreira, RSSimeonov, AJadhav, AAng, KKLeister, WShen, MSilveira, JTDoyle, PSArkin, MRMcKerrow, JHInglese, JAustin, CPThomas, CJShoichet, BKMaloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 53:52-60 (2010) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50303436
Synonyms:
9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile | CHEMBL578159
Type:
Small organic molecule
Emp. Form.:
C14H8F4N6
Mol. Mass.:
336.2471
SMILES:
FC(F)Cn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N
Structure:
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