Reaction Details Report a problem with these data
Target
Cathepsin Z
Ligand
BDBM50303441
Substrate
n/a
Meas. Tech.
ChEMBL_595889 (CHEMBL1040869)
IC50
316.23±n/a nM
Citation
 Mott, BT; Ferreira, RS; Simeonov, A; Jadhav, A; Ang, KK; Leister, W; Shen, M; Silveira, JT; Doyle, PS; Arkin, MR; McKerrow, JH; Inglese, J; Austin, CP; Thomas, CJ; Shoichet, BK; Maloney, DJ Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 53:52-60 (2010) [PubMed]  Article 
Target
Name:
Cathepsin Z
Synonyms:
CATZ_HUMAN | CTSZ | Cathepsin P | Cathepsin X
Type:
PROTEIN
Mol. Mass.:
33870.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_595889
Residue:
303
Sequence:
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
  
Inhibitor
Name:
BDBM50303441
Synonyms:
9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile | CHEMBL567134
Type:
Small organic molecule
Emp. Form.:
C14H10F2N6
Mol. Mass.:
300.2662
SMILES:
CCNc1nc(nc2n(cnc12)-c1cc(F)cc(F)c1)C#N
Structure:
Search PDB for entries with ligand similarity: