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Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM50304337
Substrate
n/a
Meas. Tech.
ChEMBL_606516 (CHEMBL1065467)
EC50
1220±n/a nM
Citation
 Le Guével, R; Oger, F; Lecorgne, A; Dudasova, Z; Chevance, S; Bondon, A; Barath, P; Simonneaux, G; Salbert, G Identification of small molecule regulators of the nuclear receptor HNF4alpha based on naphthofuran scaffolds. Bioorg Med Chem 17:7021-30 (2009) [PubMed]  Article 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM50304337
Synonyms:
2-(2-Nitro-naphtho[2,1-b]furan-1-yl)-ethanol | 2-(2-nitronaphtho[2,1-b]furan-1-yl)ethanol | CHEMBL7135
Type:
Small organic molecule
Emp. Form.:
C14H11NO4
Mol. Mass.:
257.2414
SMILES:
OCCc1c(oc2ccc3ccccc3c12)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: