Target
Oxysterols receptor LXR-beta
Ligand
BDBM50305073
Substrate
n/a
Meas. Tech.
ChEMBL_603037 (CHEMBL1047698)
IC50
3.3±n/a nM
Citation
 Bernotas, RCSinghaus, RRKaufman, DHTravins, JMUllrich, JWUnwalla, RQuinet, EEvans, MNambi, POlland, AKauppi, BWilhelmsson, AGoos-Nilsson, AWrobel, J 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists. Bioorg Med Chem Lett 20:209-12 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50305073
Synonyms:
3-benzyl-8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)quinoline | CHEMBL606539
Type:
Small organic molecule
Emp. Form.:
C29H22ClNO3S
Mol. Mass.:
500.008
SMILES:
CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(Cc3ccccc3)cnc3c(Cl)cccc23)c1
Structure:
Search PDB for entries with ligand similarity: