Reaction Details
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3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
Ligand
BDBM50311133
Substrate
n/a
Meas. Tech.
ChEMBL_619853 (CHEMBL1106730)
IC50
189±n/a nM
Citation
Bellavance, E; Luu-The, V; Poirier, D Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem 52:7488-502 (2009) [PubMed] Article More Info.:
Target
Name:
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
Synonyms:
17HSD7 | 3-keto-steroid reductase | DHB7_HUMAN | HSD17B7 | SDR37C1
Type:
PROTEIN
Mol. Mass.:
38212.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_619853
Residue:
341
Sequence:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
Inhibitor
Name:
BDBM50311133
Synonyms:
17beta-[(N-Heptyl)methylamino]-4-methyl-4-aza-5alpha-androstan-3-one | CHEMBL1080041
Type:
Small organic molecule
Emp. Form.:
C27H48N2O
Mol. Mass.:
416.6828
SMILES:
CCCCCCCN(C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure:
