Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50313634
Substrate
n/a
Meas. Tech.
ChEMBL_614474 (CHEMBL1110542)
EC50
860±n/a nM
Citation
 Bridges, TM; Phillip Kennedy, J; Noetzel, MJ; Breininger, ML; Gentry, PR; Jeffrey Conn, P; Lindsley, CW Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett 20:1972-5 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50313634
Synonyms:
1-(2,6-difluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione | CHEMBL1083204 | VU0366368
Type:
Small organic molecule
Emp. Form.:
C19H13F2N3O2
Mol. Mass.:
353.3222
SMILES:
Cn1cc(cn1)-c1cc(F)c(CN2C(=O)C(=O)c3ccccc23)c(F)c1
Structure:
Search PDB for entries with ligand similarity: