Target
Ribosomal protein S6 kinase beta-1
Ligand
BDBM50316344
Substrate
n/a
Meas. Tech.
ChEMBL_627906 (CHEMBL1103722)
IC50
97±n/a nM
Citation
 Nittoli, TDushin, RGIngalls, CCheung, KFloyd, MBFraser, HOlland, AHu, YGrosu, GHan, XArndt, KGuo, BWissner, A The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1). Eur J Med Chem 45:1379-86 (2010) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase beta-1
Synonyms:
70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1
Type:
Enzyme
Mol. Mass.:
59139.89
Organism:
Homo sapiens (Human)
Description:
His-tagged S6K1.
Residue:
525
Sequence:
MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
  
Inhibitor
Name:
BDBM50316344
Synonyms:
2-(5-{[(2R)-2-Aminopropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c]-2,7-naphthyridin-4-amine | CHEMBL1097955
Type:
Small organic molecule
Emp. Form.:
C22H23N5O3
Mol. Mass.:
405.4497
SMILES:
COc1cc2ncc3c(N)nc(cc3c2cc1OC)-c1cncc(OC[C@@H](C)N)c1 |r|
Structure:
Search PDB for entries with ligand similarity: