Target
6,7-dimethyl-8-ribityllumazine synthase
Ligand
BDBM50316576
Substrate
n/a
Meas. Tech.
ChEMBL_631469 (CHEMBL1113888)
Ki
16000±n/a nM
Citation
 Talukdar, AMorgunova, EDuan, JMeining, WFoloppe, NNilsson, LBacher, AIllarionov, BFischer, MLadenstein, RCushman, M Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase. Bioorg Med Chem 18:3518-34 (2010) [PubMed]  Article 
Target
Name:
6,7-dimethyl-8-ribityllumazine synthase
Synonyms:
RISB_MYCTU | ribH
Type:
PROTEIN
Mol. Mass.:
16367.39
Organism:
Mycobacterium tuberculosis
Description:
ChEMBL_631469
Residue:
160
Sequence:
MKGGAGVPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS
  
Inhibitor
Name:
BDBM50316576
Synonyms:
1,1-difluoro-5-(2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)pentylphosphonic acid | CHEMBL1096338
Type:
Small organic molecule
Emp. Form.:
C16H17F2N2O6PS
Mol. Mass.:
434.352
SMILES:
OP(O)(=O)C(F)(F)CCCCNS(=O)(=O)c1ccc2NC(=O)c3cccc1c23
Structure:
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