Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50049708
Substrate
n/a
Meas. Tech.
ChEMBL_659142 (CHEMBL1247087)
IC50
150±n/a nM
Citation
 Kotsakis, SD; Papagiannitsis, CC; Tzelepi, E; Legakis, NJ; Miriagou, V; Tzouvelekis, LS GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrob Agents Chemother 54:1331-3 (2010) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase GES-13
Type:
PROTEIN
Mol. Mass.:
31212.74
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_659142
Residue:
287
Sequence:
MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVDPQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVKWSPATERFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPEMNDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPKDWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQLILSTDK
  
Inhibitor
Name:
BDBM50049708
Synonyms:
CHEMBL148 | IMIPENEM
Type:
Small organic molecule
Emp. Form.:
C12H17N3O4S
Mol. Mass.:
299.346
SMILES:
C[C@@H](O)[C@@H]1[C@H]2CC(SCCN=CN)=C(N2C1=O)C(O)=O |r,w:11.11,c:12|
Structure:
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