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Target
Acidic mammalian chitinase
Ligand
BDBM50331852
Substrate
n/a
Meas. Tech.
ChEMBL_686889 (CHEMBL1291258)
IC50
>2500000±n/a nM
Citation
 Schüttelkopf, AW; Gros, L; Blair, DE; Frearson, JA; van Aalten, DM; Gilbert, IH Acetazolamide-based fungal chitinase inhibitors. Bioorg Med Chem 18:8334-40 (2010) [PubMed]  Article 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50331852
Synonyms:
8-CHLORO-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONE | 8-Chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione | 8-Chloro-theophylline | CHEMBL88611
Type:
Small organic molecule
Emp. Form.:
C7H7ClN4O2
Mol. Mass.:
214.609
SMILES:
Cn1c2nc(Cl)[nH]c2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: