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Target
Aldehyde oxidase 1
Ligand
BDBM87351
Substrate
n/a
Meas. Tech.
ChEMBL_696368 (CHEMBL1640081)
Ki
60±n/a nM
Citation
 Pryde, DC; Dalvie, D; Hu, Q; Jones, P; Obach, RS; Tran, TD Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem 53:8441-60 (2010) [PubMed]  Article 
Target
Name:
Aldehyde oxidase 1
Synonyms:
AO | AOX1 | AOXA_RABIT | Aldehyde oxidase | Retinal oxidase
Type:
PROTEIN
Mol. Mass.:
147140.36
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_696368
Residue:
1334
Sequence:
MEPAPELLFYVNGRKVVEKQVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNRVTKKIRHYPVNACLTPICSLYGAAVTTVEGIGSTTTRLHPVQERIAKFHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLADALGGNLCRCTGYRPIIEAYKTFCKTSDCCQNKENGFCCLDQGINGLPEVEEENQTRPNLFSEEEYLPLDPTQELIFPPELMTMAEKQPQRTRVFSGERMMWISPVTLKALLEAKSTYPQAPVVMGNTSVGPGVKFKGIFHPVIISPDSIEELNVVSHTHSGLTLGAGLSLAQVKDILADVVQKVPEENAQTYRALLKHLGTLAGSQIRNMASLGGHIISRHLDSDLNPLLAVGNCTLNVLSKEGERQIPLDEQFLSRCPEADLKPQEILASVHIPYSRKWEFVLAFRQAQRKQNALAIVNSGMRVFFGEGDGIIRELAISYGGVGPTIICAKNSCQKLIGRSWNEEMLDTACRLILDEVSLPGSAPGGKVEFKRTLIISFLFKFYLEVSQILKRMAPGLSPHLADKYESALQDLHARYSWSTLKDQDVDARQLSQDPIGHPVMHLSGVKHATGEAIYLDDMPAVDQELFMAFVTSPRAHAKIVSTDLLEALSLPGVVDIVTAEHLQDGNTFYTEKLLAADEVLCVGQLVCAVIAESEVQAKQAAKQVKIVYEDLEPVILSIEEAIEQKSFFEPERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSVLVVPKGEDQEMDVYASTQFPKYIQDMVAAVLKLPVNKVMCHVKRVGGAFGGKVFKASIMAAIAAFAANKHGRAVRCILERGEDMLITGGRHPYLGKYKAGFMNDGRIVALDVEHYSNGGCSLDESLLVIEMGLLKMENAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITECCITEVAAKCGLSPEKVRAINFYKEIDQTPYKQEINAKNLTQCWNECLAKSSYFQRKVAVEKFNAENYWKQRGLAIIPFKYPRGLGSVAYGQAAALVHVYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELKMPMSNVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIINKNPQGTWKEWAQAAFDKSISLSATGYFRGYDSNIDWDKGEGHPFEYFVYGAACSEVEIDCLTGDHKTIRTDIVMDVGYSINPALDIGQVEGAFIQGMGLYTIEELHYSPQGILYSRGPNQYKIPAICDIPAELNVTFLPPSEKSNTLYSSKGLGESGVFMGCSVFFAIREAVCAARQARGLSAPWKLSSPLTPEKIRMACEDKFTKMIPRDKPGSYVPWNVPV
  
Inhibitor
Name:
BDBM87351
Synonyms:
Amsacrine hydrochloride | CHEMBL43 | MLS002153376 | N-[4-(9-acridinylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride | N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide;hydrochloride | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;hydrochloride | SMR000875352 | cid_148673 | m-AMSA
Type:
Small organic molecule
Emp. Form.:
C21H19N3O3S
Mol. Mass.:
393.459
SMILES:
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: