Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase
Ligand
BDBM50336496
Substrate
n/a
Meas. Tech.
ChEMBL_716909 (CHEMBL1670937)
IC50
>100000±n/a nM
Citation
 Albrecht, S; Al-Lakkis-Wehbe, M; Orsini, A; Defoin, A; Pale, P; Salomon, E; Tarnus, C; Weibel, JM Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13. Bioorg Med Chem 19:1434-49 (2011) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_BOVIN | LAP | LAP3 | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase
Type:
Homohexamer
Mol. Mass.:
56288.28
Organism:
Bos taurus (bovine)
Description:
Bovine kidney LAPc was purchased from Sigma Chemical Co.
Residue:
519
Sequence:
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSEDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
  
Inhibitor
Name:
BDBM50336496
Synonyms:
2-aminocycloheptanone hydrochloride | CHEMBL1668627
Type:
Small organic molecule
Emp. Form.:
C7H13NO
Mol. Mass.:
127.1842
SMILES:
NC1CCCCCC1=O
Structure:
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