Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50336851
Substrate
n/a
Meas. Tech.
ChEMBL_718201 (CHEMBL1679247)
IC50
19910±n/a nM
Citation
 Gavande, N; Yamamoto, I; Salam, NK; Ai, TH; Burden, PM; Johnston, GA; Hanrahan, JR Novel Cyclic Phosphinic Acids as GABAC ρ Receptor Antagonists: Design, Synthesis, and Pharmacology ACS Med Chem Lett 2:11-16 (2011) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
  
Inhibitor
Name:
BDBM50336851
Synonyms:
3-(aminomethyl)-1-oxo-1-hydroxy-phospholane | CHEMBL1672299
Type:
Small organic molecule
Emp. Form.:
C5H12NO2P
Mol. Mass.:
149.128
SMILES:
NCC1CCP(O)(O)=C1
Structure:
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