Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50337007
Substrate
n/a
Meas. Tech.
ChEMBL_718725 (CHEMBL1680944)
EC50
>10000±n/a nM
Citation
 Qin, JRao, AChen, XZhu, XLiu, ZHuang, XDegrado, SHuang, YXiao, DAslanian, RCheewatrakoolpong, BZhang, HGreenfeder, SFarley, CCook, JKurowski, SLi, QHeek, MvChintala, MWang, GHsieh, YLi, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett 2:171-176 (2011) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50337007
Synonyms:
5-ethyl-2-(4-(trifluoromethyl)phenyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1672762
Type:
Small organic molecule
Emp. Form.:
C16H11F3N2O3
Mol. Mass.:
336.2653
SMILES:
CCc1cc(=O)oc2nc([nH]c(=O)c12)-c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: