Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50337042
Substrate
n/a
Meas. Tech.
ChEMBL_718725 (CHEMBL1680944)
EC50
130±n/a nM
Citation
 Qin, JRao, AChen, XZhu, XLiu, ZHuang, XDegrado, SHuang, YXiao, DAslanian, RCheewatrakoolpong, BZhang, HGreenfeder, SFarley, CCook, JKurowski, SLi, QHeek, MvChintala, MWang, GHsieh, YLi, F Discovery of a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia ACS Med Chem Lett 2:171-176 (2011) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50337042
Synonyms:
2-(difluoromethyl)-5-(2-(spiro[2.3]hexan-5-yl)ethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione | CHEMBL1672738
Type:
Small organic molecule
Emp. Form.:
C16H16F2N2O3
Mol. Mass.:
322.3066
SMILES:
FC(F)c1nc2oc(=O)cc(CCC3CC4(CC4)C3)c2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: