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Target
Tyrosinase
Ligand
BDBM50340789
Substrate
n/a
Meas. Tech.
ChEMBL_740266 (CHEMBL1764166)
IC50
830±n/a nM
Citation
 Tajima, R; Oozeki, H; Muraoka, S; Tanaka, S; Motegi, Y; Nihei, H; Yamada, Y; Masuoka, N; Nihei, K Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem 46:1374-81 (2011) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50340789
Synonyms:
2,2',4'-Trihydroxy-4-(beta-D-maltopyranosyl)bibenzyl | CHEMBL1760464
Type:
Small organic molecule
Emp. Form.:
C26H34O14
Mol. Mass.:
570.5398
SMILES:
OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](Oc3ccc(CCc4ccc(O)cc4O)c(O)c3)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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