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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50342096
Substrate
n/a
Meas. Tech.
ChEMBL_743931 (CHEMBL1767925)
Ki
1.9±n/a nM
Citation
 Ezzili, C; Mileni, M; McGlinchey, N; Long, JZ; Kinsey, SG; Hochstatter, DG; Stevens, RC; Lichtman, AH; Cravatt, BF; Bilsky, EJ; Boger, DL Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem 54:2805-22 (2011) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50342096
Synonyms:
(S)-(5-phenyl-2,3-dihydro-1H-inden-2-yl)(5-(pyridin-2-yl)oxazol-2-yl)methanone | CHEMBL1765862
Type:
Small organic molecule
Emp. Form.:
C24H18N2O2
Mol. Mass.:
366.4119
SMILES:
O=C([C@H]1Cc2ccc(cc2C1)-c1ccccc1)c1ncc(o1)-c1ccccn1 |r|
Structure:
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