Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM50347319
Substrate
n/a
Meas. Tech.
ChEMBL_754315 (CHEMBL1799091)
IC50
9±n/a nM
Citation
 Ngu, KWeinstein, DSLiu, WLangevine, CCombs, DWZhuang, SChen, XMadsen, CSHarper, TWAhmad, SRobl, JA Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase. Bioorg Med Chem Lett 21:4141-5 (2011) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase
Type:
Enzyme
Mol. Mass.:
75309.71
Organism:
Oryctolagus cuniculus (rabbit)
Description:
15-LO enzyme was purified from phenylhydrazine treated rabbits.
Residue:
663
Sequence:
MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSLLFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGDPQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLAWGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPMLLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAPLVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNSHLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMSTGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIMGLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQHSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRDQPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENSVAI
  
Inhibitor
Name:
BDBM50347319
Synonyms:
CHEMBL1796841
Type:
Small organic molecule
Emp. Form.:
C27H31N3O3S2
Mol. Mass.:
509.683
SMILES:
CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c(n[nH]c1-c1cccs1)-c1cccc(OC)c1
Structure:
Search PDB for entries with ligand similarity: