Reaction Details Report a problem with these data
Target
Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Ligand
BDBM50350725
Substrate
n/a
Meas. Tech.
ChEMBL_762857 (CHEMBL1820674)
Ki
5300±n/a nM
Citation
 Walker, SR; Jiao, W; Parker, EJ Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorg Med Chem Lett 21:5092-7 (2011) [PubMed]  Article 
Target
Name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Synonyms:
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase, Phe-sensitive | AROG_ECOLI | aroG
Type:
PROTEIN
Mol. Mass.:
38009.60
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_762857
Residue:
350
Sequence:
MNYQNDDLRIKEIKELLPPVALLEKFPATENAANTVAHARKAIHKILKGNDDRLLVVIGPCSIHDPVAAKEYATRLLALREELKDELEIVMRVYFEKPRTTVGWKGLINDPHMDNSFQINDGLRIARKLLLDINDSGLPAAGEFLDMITPQYLADLMSWGAIGARTTESQVHRELASGLSCPVGFKNGTDGTIKVAIDAINAAGAPHCFLSVTKWGHSAIVNTSGNGDCHIILRGGKEPNYSAKHVAEVKEGLNKAGLPAQVMIDFSHANSSKQFKKQMDVCADVCQQIAGGEKAIIGVMVESHLVEGNQSLESGEPLAYGKSITDACIGWEDTDALLRQLANAVKARRG
  
Inhibitor
Name:
BDBM50350725
Synonyms:
CHEMBL1818157 | CHEMBL1818158
Type:
Small organic molecule
Emp. Form.:
C8H16O9P2
Mol. Mass.:
318.1548
SMILES:
OC(=O)C(CP(O)(O)=O)=CCCCCOP(O)(O)=O |w:9.9|
Structure:
Search PDB for entries with ligand similarity: