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Target
Kinesin-1 heavy chain
Ligand
BDBM50353788
Substrate
n/a
Meas. Tech.
ChEMBL_770435 (CHEMBL1833744)
IC50
>100000±n/a nM
Citation
 Theoclitou, ME; Aquila, B; Block, MH; Brassil, PJ; Castriotta, L; Code, E; Collins, MP; Davies, AM; Deegan, T; Ezhuthachan, J; Filla, S; Freed, E; Hu, H; Huszar, D; Jayaraman, M; Lawson, D; Lewis, PM; Nadella, MV; Oza, V; Padmanilayam, M; Pontz, T; Ronco, L; Russell, D; Whitston, D; Zheng, X Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem 54:6734-50 (2011) [PubMed]  Article 
Target
Name:
Kinesin-1 heavy chain
Synonyms:
KIF5B | KINH_HUMAN | KNS | KNS1
Type:
PROTEIN
Mol. Mass.:
109682.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_770435
Residue:
963
Sequence:
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGGKQV
  
Inhibitor
Name:
BDBM50353788
Synonyms:
CHEMBL1829433
Type:
Small organic molecule
Emp. Form.:
C28H33N5O2S
Mol. Mass.:
503.659
SMILES:
CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1
Structure:
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