Target
Acyl-CoA desaturase 1
Ligand
BDBM50305768
Substrate
n/a
Meas. Tech.
ChEMBL_785447 (CHEMBL1919826)
IC50
2±n/a nM
Citation
 Leclerc, JPFalgueyret, JPGirardin, MGuay, JGuiral, SHuang, ZLi, CSOballa, RRamtohul, YKSkorey, KTawa, PWang, HZhang, L Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors. Bioorg Med Chem Lett 21:6505-9 (2011) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50305768
Synonyms:
2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole | CHEMBL594902 | MF-438
Type:
Small organic molecule
Emp. Form.:
C19H18F3N5OS
Mol. Mass.:
421.439
SMILES:
Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: