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Target
Proton-coupled amino acid transporter 1
Ligand
BDBM50000100
Substrate
n/a
Meas. Tech.
ChEMBL_788189 (CHEMBL1919336)
Ki
1600000±n/a nM
Citation
 Thondorf, I; Voigt, V; Schäfer, S; Gebauer, S; Zebisch, K; Laug, L; Brandsch, M Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Bioorg Med Chem 19:6409-18 (2011) [PubMed]  Article 
Target
Name:
Proton-coupled amino acid transporter 1
Synonyms:
PAT1 | Proton/amino acid transporter 1 | S36A1_HUMAN | SLC36A1 | Solute carrier family 36 member 1 | hPAT1
Type:
PROTEIN
Mol. Mass.:
53078.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_788189
Residue:
476
Sequence:
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
  
Inhibitor
Name:
BDBM50000100
Synonyms:
(-)-(S)-proline | (-)-2-pyrrolidinecarboxylic acid | (-)-proline | (2S)-pyrrolidine-2-carboxylic acid | (S)-2-carboxypyrrolidine | (S)-2-pyrrolidinecarboxylic acid | (S)-pyrrolidine-2-carboxylic acid | CHEMBL54922 | L-(-)-proline | L-Prolin | L-alpha-pyrrolidinecarboxylic acid | L-proline | L-pyrrolidine-2-carboxylic acid | prolina | prolinum
Type:
Small organic molecule
Emp. Form.:
C5H9NO2
Mol. Mass.:
115.1305
SMILES:
OC(=O)[C@@H]1CCCN1
Structure:
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