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Target
Squalene synthase
Ligand
BDBM50357699
Substrate
n/a
Meas. Tech.
ChEMBL_785902 (CHEMBL1921212)
IC50
4900±n/a nM
Citation
 Matralis, AN; Katselou, MG; Nikitakis, A; Kourounakis, AP Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents. J Med Chem 54:5583-91 (2011) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50357699
Synonyms:
CHEMBL1915486
Type:
Small organic molecule
Emp. Form.:
C21H19NS
Mol. Mass.:
317.447
SMILES:
CN1CC(Sc2ccccc12)c1ccc(cc1)-c1ccccc1
Structure:
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