Reaction Details Report a problem with these data
Target
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Ligand
BDBM50357883
Substrate
n/a
Meas. Tech.
ChEMBL_787631 (CHEMBL1918084)
Kd
>5000±n/a nM
Citation
 Anraku, K; Inoue, T; Sugimoto, K; Kudo, K; Okamoto, Y; Morii, T; Mori, Y; Otsuka, M Design and synthesis of biotinylated inositol 1,3,4,5-tetrakisphosphate targeting Grp1 pleckstrin homology domain. Bioorg Med Chem 19:6833-41 (2011) [PubMed]  Article 
Target
Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Synonyms:
PLC-III | PLC-delta-1 | PLCD1_RAT | Phosphoinositide phospholipase C-delta-1 | Phospholipase C-III | Phospholipase C-delta-1 | Plcd1
Type:
PROTEIN
Mol. Mass.:
85958.21
Organism:
Rattus norvegicus
Description:
ChEMBL_787631
Residue:
756
Sequence:
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAFEEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRAILGPILLDQPLDGVTTSLPSPEQLKGKILLKGKKLGGLLPAGGENGSEATDVSDEVEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFSSPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGPWWRPERLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTGSRQTAVITNNGFNPRWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDQHPSATLFVKISIQD
  
Inhibitor
Name:
BDBM50357883
Synonyms:
CHEMBL1916342
Type:
Small organic molecule
Emp. Form.:
C22H42N3O17P3S
Mol. Mass.:
745.565
SMILES:
O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(=O)OCCCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 |r|
Structure:
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