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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50156055
Substrate
n/a
Meas. Tech.
ChEMBL_807237 (CHEMBL1960167)
IC50
4300±n/a nM
Citation
 Dunn, D; Hostetler, G; Iqbal, M; Messina-McLaughlin, P; Reiboldt, A; Lin, YG; Gruner, J; Bacon, ER; Ator, MA; Chatterjee, S Wake-promoting agents: search for next generation modafinil: part I. Bioorg Med Chem Lett 22:2312-4 (2012) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50156055
Synonyms:
2-(Diphenyl-methanesulfinyl)-acetamide | 2-(benzhydrylsulfinyl)acetamide | 2-[(diphenylmethyl)sulfinyl]acetamide | Ambrisentan | CEP-1538 | CHEMBL1373 | CRL-40476 | MODAFINIL | Provigil | US10913711, Compound (+-)-modafinilb | US11555013, Compound (+-)-modafinilb | US9862679, Compound (+-)-modafinil
Type:
Small organic molecule
Emp. Form.:
C15H15NO2S
Mol. Mass.:
273.35
SMILES:
NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: