Reaction Details Report a problem with these data
Target
Inositol-trisphosphate 3-kinase C
Ligand
BDBM50040911
Substrate
n/a
Meas. Tech.
ChEBML_90248
Ki
978000±n/a nM
Citation
 Liu, C; Safrany, ST; Nahorski, SR; Potter, BV Synthesis of L-chiro-inositol 1,4,6-trisphosphorothioate, a potent and selective inhibitor of myo-inositol 1,4,5-trisphosphate 5-phosphatase Bioorg Med Chem Lett 2:1523-1528 (1992)    Article 
Target
Name:
Inositol-trisphosphate 3-kinase C
Synonyms:
IP3KC_RAT | Inositol 1,4,5-trisphosphate 3 kinase C | Ip3kc | Itpkc
Type:
PROTEIN
Mol. Mass.:
74440.10
Organism:
Rattus norvegicus
Description:
ChEMBL_90248
Residue:
678
Sequence:
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEGFSLHSEAERTDFGPAPCPDGPQAEPCGDEHEECEAAGLGVASEKPSQNKELDGSNLQTHPKLSSPLAEMEMAGSWTDGFRTDLHRPDLQARPKRASLCTQPGFDESWTELDRSELWQTLPERDKPWVDHLRTHQDMSRLQNHPACPSPEPSAGTSCKELSADGSRTPHDTDGFWIESQTDGSLIGPSTQTACRQPANDGFSAQDTDGTLIQPGTDDGPWVDSVLEKSNGDDPLMEPEPRDLVTNLCSHLECSSLCPVPRLIITSESPEPGAQPLGPQARIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRSGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPTYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDVGILRKYVARLEDLRDTLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWAEGNREDGYLWGLDNLICLLQGLAQS
  
Inhibitor
Name:
BDBM50040911
Synonyms:
(+)-myo-inositol 1,4,5-trisphosphorothioate | (-)-chiro-inositol 1,4,6-trisphosphorothioate | 1,4,5-trisphosphate 5-phosphatase derivatives | Inositol 1,4,5-trisphosphorothioate | L-(1,4,5)PS3 | {[2,5-bis({[dioxido(sulfanylidene)--phosphanyl]oxy})-3,4,6-trihydroxycyclohexyl]oxy}(sulfanylidene)phosphonite
Type:
Small organic molecule
Emp. Form.:
C6H9O12P3S3
Mol. Mass.:
462.248
SMILES:
OC1C(O)C(OP([O-])([O-])=S)C(OP([O-])([O-])=S)C(O)C1OP([O-])([O-])=S
Structure:
Search PDB for entries with ligand similarity: