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Target
Tyrosinase
Ligand
BDBM50287123
Substrate
n/a
Meas. Tech.
ChEBML_210708
IC50
2390±n/a nM
Citation
 Kobayashi, Y; Kayahara, H; Tadasa, K; Tanaka, H Synthesis of N-kojic-amino acid and N-kojic-amino acid-kojiate and their tyrosinase inhibitory activity Bioorg Med Chem Lett 6:1303-1308 (1996)    Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50287123
Synonyms:
(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbonylamino)-3-methyl-butyric acid 5-hydroxy-4-oxo-4H-pyran-2-ylmethyl ester | CHEMBL25350
Type:
Small organic molecule
Emp. Form.:
C18H19NO10
Mol. Mass.:
409.3442
SMILES:
CC(C)[C@H](NC(=O)OCc1cc(=O)c(O)co1)C(=O)OCc1cc(=O)c(O)co1
Structure:
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