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Target
Squalene synthase
Ligand
BDBM50290882
Substrate
n/a
Meas. Tech.
ChEMBL_202119 (CHEMBL873256)
IC50
57000±n/a nM
Citation
 Wattanasin, S; Boettcher, BR; Scallen, T N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase Bioorg Med Chem Lett 7:3039-3044 (1997)    Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50290882
Synonyms:
CHEMBL102521 | N-hydroxyglycine derivative
Type:
Small organic molecule
Emp. Form.:
C22H31N2O5
Mol. Mass.:
403.4925
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#8]-c1cccc(-[#6]-[#7]-[#6](=O)-[#7](-[#8])C([#6])([#6])[#6](-[#8-])=O)c1
Structure:
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