Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM81462
Substrate
n/a
Meas. Tech.
ChEBML_139794
IC50
6.7±n/a nM
Citation
 Augelli-Szafran, CEJaen, JCMoreland, DWNelson, CBPenvose-Yi, JRSchwarz, RD Identification and characterization of m4 selective muscarinic antagonists. Bioorg Med Chem Lett 8:1991-6 (1999) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM81462
Synonyms:
(R)-Trihexyphenidyl | (S)-Trihexyphenidyl | Benzhexol | CAS_58947-95-8 | NSC_5572 | TRIHEXYPHENIDYL HYDROCHLORIDE | Trihexyphenidyl
Type:
Small organic molecule
Emp. Form.:
C20H31NO
Mol. Mass.:
301.4662
SMILES:
OC(CCN1CCCCC1)(C1CCCCC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: