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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50072260
Substrate
n/a
Meas. Tech.
ChEMBL_216337 (CHEMBL818751)
IC50
950±n/a nM
Citation
 Giordani, A; Pevarello, P; Cini, M; Bormetti, R; Greco, F; Toma, S; Speciale, C; Varasi, M 4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase. Bioorg Med Chem Lett 8:2907-12 (1999) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_RAT | Kmo
Type:
PROTEIN
Mol. Mass.:
54371.88
Organism:
Rattus norvegicus
Description:
ChEMBL_1487468
Residue:
478
Sequence:
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
  
Inhibitor
Name:
BDBM50072260
Synonyms:
(Z)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid | 4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid (0.2H2O) | CHEMBL22480
Type:
Small organic molecule
Emp. Form.:
C10H6Cl2O4
Mol. Mass.:
261.058
SMILES:
OC(=O)C(=O)CC(=O)c1ccc(Cl)c(Cl)c1
Structure:
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